Multiple Marker Screening (MMS)

Data Definition: Date of NT Measurement

Data Definition: If applicable, indicates third doctor's name recorded on requisition form.

Data Definition: SERUM only: Specimen number of the second sample or second trimester sample assigned by the individual screening lab. PS MSH lab: specimen number assigned to second trimester samples; Other PS labs (except for PS NYGH lab): specimen number of the second sample received by the laboratory (eg IPS2)

Data Definition: Unique ID of Scan Centre where prenatal screening dating ultrasound was completed.

Data Definition: Sonographer coefficient set used for generating NT sonographer specific curve.

Data Definition: Indicates if the screened pregnancy was conceived through in vitro fertilization (IVF).

Data Definition: Date of birth of egg donor.

Data Definition: Age at EDB of egg donor.

Data Definition: Date the embryo transfer occurred.

Data Definition: Calendar day, month, year the second sample was received by the prenatal screening laboratory.

Data Definition: Pregnant person's age at estimated date of birth (EDB) with one decimal.

Data Definition: Estimated date of birth as per ultrasound or Nägele's rule.

Data Definition: Gestational age (GA) in days determined by ultrasound (US).

Data Definition: Gestational age in days determined using dates of last normal menstrual period.

Data Definition: Gestational age in days determined by Ultrasound (US) at date second Multiple Marker Serum Screen sample is obtained.

Data Definition: Gestational age in days determined by calculation of last normal menstrual period dates at date first Multiple Marker Serum Screen sample is obtained.

Data Definition: Gestational age in days determined by Ultrasound (US) at date second Multiple Marker Serum Screen sample is obtained.

Data Definition: Gestational age in days determined by calculation of last normal menstrual period dates at date second Multiple Marker Serum sample is obtained.

Data Definition: Number of fetuses in the current pregnancy. For Prenatal Screening Follow Up encounters, this field refers to the number of fetuses that the prenatal screening result was based on.

Data Definition: Pregnant person's Ontario Health Insurance Plan (OHIP) number without version code. Other number type when OHIP is not available (for example, RAMQ).

Data Definition: Pregnant person's family name as it appears on official health card. If not available, full legal name.

Data Definition: Pregnant person's date of birth in the format of day, month, year.

Data Definition: Postal code of pregnant person's usual or permanent address closest to the time of conception.

Data Definition: City or municipality of the pregnant person's mailing or permanent address closest to the time of conception

Data Definition: Indicates if the pregnant person had insulin dependant diabetes prior to pregnancy.

Data Definition: Date (day, month, year) of the first day of the person's last known menstrual period. (Cunningham, 2005)

Data Definition: Pregnant person's weight recorded at the time of Multiple Marker Screen (measured in kilograms).

Data Definition: Nature of the zygotes from which individuals are derived; e.g., whether by separation of the division of one zygote (monozygotic), in which case they will be genetically identical, or from two separate fertilized ova (dizygotic).

Data Definition: Unique identification number assigned to a test for Multiple Marker Serum Screen and fluid test record.

Data Definition:

Data Definition:

Data Definition:

Data Definition:

Data Definition: Prenatal Screening Ontario-assigned unique identification code for the sonographer performing Nuchal Translucency Measurement.

Data Definition: Date (day, month, year) of first sample collection in standard date format.

Data Definition: Date (day, month, year) of second sample collection in standard date format.

Data Definition:

Data Definition: Reported measurement level of alpha-fetoprotein (AFP) assay result based on serum screen and fluid test.

Data Definition: Reported measurement level of unconjugated estriol level (uE3) assay result based on serum screen. (Cunningham, 2005)

Data Definition: Reported total level of human chorionic gonadotrophin (hCG) assay result. (Cunningham, 2005)

Data Definition: Measurement of the nuchal translucency (NT), an echolucent area seen in longitudinal views of the back of the neck on ultrasound reported in millimeters. (Cunningham, 2005)

Data Definition: Measurement of free ß human chorionic gonadotropin (Fß-hCG) assay result (unadjusted). (Cunningham, 2005)

Data Definition: Measurement of pregnancy-associated plasma protein A (PAPP-A) assay result (unadjusted). (Cunningham, 2005)

Data Definition: Measurement of dimeric inhibin A (DIA) assay result (unadjusted). (Cunningham, 2005)

Data Definition: Date (calendar day, month, year) PS result report is issued using standard date format.

Data Definition: Date (calendar day, month, year) of ultrasonography used for interpretation.

Data Definition: Indicates if the pregnant person smoked at time of conception.

Data Definition: Multiples of the median level of alpha-fetoprotein (AFP).

Data Definition: Reported measurement level of unconjugated estriol level (uE3) assay result based on serum screen. (Cunningham, 2005)

Data Definition: Serum human chorionic gonadotropin (HCG) level measured in nanograms per millilitre and reported as a multiple of the median (MoM) of the unaffected population. (Cunningham, 2005)

Data Definition: Measurement of the nuchal translucency (NT), an echolucent area seen in longitudinal views of the back of the neck on ultrasound expressed as a multiple of the mean (MoM) NT can be combined with serum analytes to calculate a composite risk for Down Syndrome. (Cunningham, 2005)

Data Definition: Measurement of free beta subunit of human chorionic gonadotropin Fß-hCG expressed as a multiple of the mean (MoM). (Cunningham, 2005)

Data Definition: Measurement of pregnancy-associated plasma protein A (PAPP-A) expressed as a multiple of the mean (MoM). (Cunningham, 2005)

Data Definition: Measurement of dimeric inhibin A (DIA) expressed as a multiple of the mean (MoM). (Cunningham, 2005)

Data Definition: Indicates if result for the screened anomalies is positive, negative or uninterpretable.

Data Definition: Pregnant person's calculated age related risk for Down syndrome (unrounded).

Data Definition: Term risk of Down Syndrome estimated by multiplying pregnant person age related risk by a likelihood ratio determined by the measurement of their screening markers. (Cunningham, 2005)

Data Definition: Term risk of Down Syndrome estimated in unrounded form. Down Syndrome risk is obtained by multiplying pregnant person age related risk by a likelihood ratio determined by the measurements of their screening markers. (Cunningham, 2005)

Data Definition: Term risk of Down Syndrome (Numerator part of Down Syndrome risk estimation).

Data Definition: Term risk of Down Syndrome calculated from right hand side of the maternal age specific risk and multiplied by the likelihood ratio expressed as an unrounded figure. (Cunningham, 2005)

Data Definition: Background risk of an open Neural Tube Defect (NTD).

Data Definition: Calculated risk of an open neural tube defect (NTD).

Data Definition: Calculated pregnant person risk of neural tube defects expressed as an unrounded figure.

Data Definition: Numerator part of open Neural Tube Defect (NTD) risk estimation.

Data Definition: Risk of an open neural tube defect (NTD) calculated from right hand side of the likelihood ratio, expressed as an unrounded figure (Cunningham, 2005).

Data Definition: Pregnant person age related risk of Trisomy 18.

Data Definition: Calculated term risk of Trisomy 18.

Data Definition: MMMSS0068

Data Definition: Numerator part of term Trisomy 18 risk calculation.

Data Definition: Term risk of Trisomy 18 calculated from right hand side of the pregnant person age specific risk and multiplied by the likelihood ratio, expressed as an unrounded figure. (Cunningham, 2005)

Data Definition: Unique assigned Ultrasound Machine Number.

Data Definition: Calendar day, month, year the first sample was received by the prenatal screening laboratory.

Data Definition: Unique identification number and name of testing centre (lab) where PS specimen has been analyzed.

Data Definition: Indicates if a Multiple Marker Screening Test is a repeat test.

Data Definition: Unique ID of PS sample collection lab

Data Definition: SLOS population risk

Data Definition: SLOS population risk unrounded

Data Definition: SLOS risk

Data Definition: SLOS unrounded

Data Definition: Numerator part of term Trisomy SLOS risk calculation.

Data Definition: Denominator part of term Trisomy SLOS risk calculation.

Data Definition: NTD population risk

Data Definition: Age related Down syndrome risk

Data Definition: Age related Trisomy 18 risk

Data Definition: Measurement of first trimester human chorionic gonadotrophin

Data Definition: Measurement of first trimester human chorionic gonadotrophin expressed at MOM

Data Definition: Pregnant person's weight at the second PSO sample.

Data Definition: Date of AFP measurement

Data Definition: Date of uE3 measurement

Data Definition: Date of 2nd trimester total hCG measurement

Data Definition: Date of DIA measurement

Data Definition: Date of PAPP-A measurement

Data Definition: Date of Fß-hCG measurement

Data Definition: Date of 1st trimester total hCG measurement

Data Definition: Address for screening result

Data Definition: Address for screening result

Data Definition: Address for screening result

Data Definition: Indication of oral contraception use before and/or during pregnancy

Data Definition: Date donor's egg was collected

Data Definition: Type of prenatal screening (e.g. integrated prenatal screening, first trimester screening, second trimester screening, etc).

Data Definition: Screening result is positive for Down syndrome. Calculated value indicating if a pregnant person's prenatal screening result is positive/negative for Down Syndrome.

Data Definition: Screening result is positive for ONTD. Calculated value indicating if a pregnant person's prenatal screening result is positive/negative for ONTD.

Data Definition: Screening result is positive for Trisomy 18. Calculated value indicating if a pregnant person's prenatal screening result is positive/negative for Trisomy 18.

Data Definition: Delta value of NT

Data Definition: Delta value of NT of the second fetus of a twin pregnancy

Data Definition: Date pregnant person's information is entered in the screening software.

Data Definition: PlGF (1T) level

Data Definition: PlGF (1T) MoM

Data Definition: PlGF (1T) MoM adjusted

Data Definition: PlGF (1T) Assay Date

Data Definition: MS-AFP (1T) level

Data Definition: MS-AFP (1T) MoM

Data Definition: MS-AFP (1T) MoM adjusted

Data Definition: MS-AFP (1T) Assay Date

Data Definition: Method by which the estimated date of birth was determined for prenatal screening

Data Definition: Adjusted MoM value of second trimester serum AFP. Not in the current PNS lab feed.

Data Definition: Adjusted MoM value of second trimester serum uE3. Not in the current PNS lab feed.

Data Definition: Adjusted MoM value of second trimester serum hCG. Not in the current PNS lab feed.

Data Definition: Adjusted MoM value of second trimester serum DIA. Not in the current PNS lab feed.

Data Definition: Adjusted MoM value of first trimester serum PAPP-A. Not in the current PNS lab feed.

Data Definition: Adjusted MoM value of first trimester serum Fß-hCG. Not in the current PNS lab feed.

Data Definition: Adjusted MoM value of first trimester serum total hCG. Not in the current PNS lab feed.

Data Definition: Indicates if there has been fetal chromosome studies in the current pregnancy.

Data Definition: Defines the type of PS Screening. Values are Fluid and Serum

Data Definition: Date on which GA was determined by scan

Data Definition: Note spare fields could be used for different info in serum and fluid dataset (e.g. spare 4 (serum dataset) and spare 3 (fluid dataset) are used to identify counselling centres at one lab)

Data Definition: Note spare fields could be used for different info in serum and fluid dataset (e.g. spare 4 (serum dataset) and spare 3 (fluid dataset) are used to identify counselling centres at one lab)

Data Definition: Note spare fields could be used for different info in serum and fluid dataset (e.g. spare 4 (serum dataset) and spare 3 (fluid dataset) are used to identify counselling centres at one lab)

Data Definition: Note spare fields could be used for different info in serum and fluid dataset (e.g. spare 4 (serum dataset) and spare 3 (fluid dataset) are used to identify counselling centres at one lab)

Data Definition: Estimated date of birth (EDB) calculated by the screening software.

Data Definition: B value of a sonographer’s coefficient set

Data Definition: Fetal ID of a multiple pregnancy

Data Definition: Pregnant person's date of birth.

Data Definition: Ancestry of pregnant person as identified by the ordering health care provider on the prenatal screening requisition.

Data Definition:

Data Definition: Termination of pregnancy indicated by laboratory feeds.

Data Definition:

Data Definition: Refers to chorionicity of the pregnancy.

Data Definition: Down syndrome risk cut-off

Data Definition: NYGH and CVH have made a change to their screening test for ONTD using MS-AFP. A new data element Interpretation identifies pregnancies that have an ONTD test

Data Definition:

Data Definition: NTD risk cut-off

Data Definition: Sonographer coefficient set P0

Data Definition: Sonographer coefficient set P1

Data Definition: Sonographer coefficient set P2

Data Definition: Trisomy 18 risk cut-off

Data Definition: Test panel ID (Provided by MSH)

Data Definition: Test panel Name (Provided by MSH)

Data Definition: Valid version record

Data Definition: Multiple of median of nuchal translucency of second fetus for monozygotic pregnancy.

Data Definition: Risk for Down syndrome of fetus 2.

Data Definition: First doctor's name on the requisition form.

Data Definition: If applicable, second doctor's name on the requisition form.

Data Definition: Nuchal translucency measurement (in mm) of fetus 2 for monozygotic twin pregnancy.